Article
Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
Toxicology letters - 29 Aug 2013
Kienhuis Anne S, Vitins Alexa P, Pennings Jeroen L A, Pronk Tessa E, Speksnijder Ewoud N, Roodbergen Marianne, van Delft Joost H M, Luijten Mirjam, van der Ven Leo T M
Abstract excerpt
In vitro models for hepatotoxicity testing are a necessity for advancement of toxicological research. Assessing the in vitro response requires in vivo validated gene sets reflective of the hepatotoxic phenotype. Cholestasis, the impairment of bile flow, is induced in C57BL/6J mice treated with cy...
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