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Article

Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.

PloS one - 1 Jan 2014

Pandey Vikash, Sultan Marc, Kashofer Karl, Ralser Meryem, Amstislavskiy Vyacheslav, Starmann Julia, Osprian Ingrid, Grimm Christina, Hache Hendrik, Yaspo Marie-Laure, Sültmann Holger, Trauner Michael, Denk Helmut, Zatloukal Kurt, Lehrach Hans, Wierling Christoph

Abstract excerpt

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation, ballooning and degradation of hepatocytes, and fibrosis. Ultimately, steatohepatitis can result in liver cirrhosis and hepatocellular carcinoma. METHODOLOGY AND...

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Identifiers

PMID: 25347188
DOI: 10.1371/journal.pone.0111006
PMCID: PMC4210132

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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