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Article

Targeting the IL-6 dependent phenotype can identify novel therapies for cholangiocarcinoma.

PloS one - 16 Dec 2010

Braconi Chiara, Swenson Erica, Kogure Takayuki, Huang Nianyuan, Patel Tushar

Abstract excerpt

BACKGROUND: The need for new therapies for cholangiocarcinoma is highlighted by their poor prognosis and refractoriness to chemotherapy. Increased production of Interleukin-6 promotes cholangiocarcinoma growth and contributes to chemoresistance by activating cell survival mechanisms. We sought to identify biologically active compounds capable of ameliorating the phenotypic effects of IL-6 expression and to...

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Identifiers

PMID: 21179572
DOI: 10.1371/journal.pone.0015195
PMCID: PMC3002961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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