Article
Value of interleukin-28B genetic polymorphism on retreatment outcomes of chronic hepatitis C genotype 1 relapsers by peginterferon alfa plus ribavirin.
Journal of gastroenterology and hepatology - 1 Jan 2014
Chen Ming-Yao, Liu Chen-Hua, Chen Ting-Chih, Su Tung-Hung, Chen Pei-Jer, Chen Ding-Shinn, Kao Jia-Horng, Liu Chun-Jen
Abstract excerpt
BACKGROUND AND AIM: Chronic hepatitis C (CHC) infection is a leading cause of cirrhosis and hepatocellular carcinoma worldwide. Pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy remains the standard of care for CHC genotype 1 in many Asian countries, and single nucleotide polymorphism or genotype of the interleukin-28B (IL28B) gene is associated with the development of sustained virologic...
Topics
- Aged
- Antiviral Agents
- Drug Therapy, Combination
- Female
- Genotype
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Interferons
- Interleukins
- Male
- Middle Aged
- Multivariate Analysis