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Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

24 Jul 2020

Abstract excerpt

Abstract Aims/hypothesis IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of obese and type 2 diabetic individuals. Methods DNA methylation of seven CpG sites was...

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PMID: 32710190
DOI: 10.1007/s00125-020-05212-6

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