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Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood.

Analytical and bioanalytical chemistry - 1 Sept 2013

Ran Ran, Li Longyun, Wang Mengzhao, Wang Shulan, Zheng Zhi, Lin Peter Ping

Abstract excerpt

A minimally invasive and repeatable approach for real-time epidermal growth factor receptor (EGFR) mutation surveillance would be highly beneficial for individualized therapy of late stage lung cancer patients whose surgical specimens are often not available. We aim to develop a viable method to detect EGFR mutations in single circulating tumor cells (CTCs). Using a model CTC system of spiked tumor cells in whole...

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Identifiers

PMID: 23828210
DOI: 10.1007/s00216-013-7156-y

Genes

EGFR

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