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Article

Detection of mutations in EGFR in circulating lung-cancer cells.

The New England journal of medicine - 24 Jul 2008

Maheswaran Shyamala, Sequist Lecia V, Nagrath Sunitha, Ulkus Lindsey, Brannigan Brian, Collura Chey V, Inserra Elizabeth, Diederichs Sven, Iafrate A John, Bell Daphne W, Digumarthy Subba, Muzikansky Alona, Irimia Daniel, Settleman Jeffrey, Tompkins Ronald G, Lynch Thomas J, Toner Mehmet, Haber Daniel A

Abstract excerpt

BACKGROUND: The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a stra...

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Source

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Identifiers

PMID: 18596266
DOI: 10.1056/NEJMoa0800668
PMCID: PMC3551471

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18596266-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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