Article
Circulating EGFR Mutations in Patients with Lung Adenocarcinoma by Circulating Tumor Cell Isolation Systems: A Concordance Study.
International journal of molecular sciences - 13 Sept 2022
Li Shih-Hong, Wu Min-Hsien, Wang Hung-Ming, Hsu Ping-Chih, Fang Yueh-Fu, Wang Chih-Liang, Chu Hui-Chun, Lin Hung-Chih, Lee Li-Yu, Wu Ching-Yang, Yang Cheng-Ta, Chen Jen-Shi, Hsieh Jason Chia-Hsun
Abstract excerpt
Background: We developed a hybrid platform using a negative combined with a positive selection strategy to capture circulating tumor cells (CTCs) and detect epidermal growth factor receptor (EGFR) mutations in patients with metastatic lung adenocarcinoma. Methods: Blood samples were collected from patients with pathology-proven treatment-naïve stage IV lung adenocarcinoma. Genomic DNA was extracted from CTCs...
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