Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.

doi:10.1093/nar/gku1033

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Article

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.

Nucleic acids research - 10 Nov 2014

Bollmann Franziska, Art Julia, Henke Jenny, Schrick Katharina, Besche Verena, Bros Matthias, Li Huige, Siuda Daniel, Handler Norbert, Bauer Florian, Erker Thomas, Behnke Felix, Mönch Bettina, Härdle Lorena, Hoffmann Markus, Chen Ching-Yi, Förstermann Ulrich, Dirsch Verena M, Werz Oliver, Kleinert Hartmut, Pautz Andrea

Abstract excerpt

Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory resveratrol effects deserve more attention. In human epithelial DLD-1 and monocytic Mono Mac 6 cells resveratrol decreased the expression of iNOS, IL-8 and TNF-α by reducing mRNA stability without inhibition of the promoter...

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PMID: 25352548
DOI: 10.1093/nar/gku1033
PMCID: PMC4227754

Genes

TNF
DLD
SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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