Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Environmental dependence of genetic constraint.

PLoS genetics - 1 Jun 2013

de Vos Marjon G J, Poelwijk Frank J, Battich Nico, Ndika Joseph D T, Tans Sander J

Abstract excerpt

The epistatic interactions that underlie evolutionary constraint have mainly been studied for constant external conditions. However, environmental changes may modulate epistasis and hence affect genetic constraints. Here we investigate genetic constraints in the adaptive evolution of a novel regulatory function in variable environments, using the lac repressor, LacI, as a model system. We have systematically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Escherichia coli K12
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene-Environment Interaction

Share to Lac Repressors

Share to Models, Genetic

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 23825963
DOI: 10.1371/journal.pgen.1003580
PMCID: PMC3694820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Environmental dependence of genetic constraint.PMID 23825963Read ↗

Tradeoffs and optimality in the evolution of gene regulation.Semantic proximity Read ↗

Epistasis shapes the fitness landscape of an allosteric specificity switch.Semantic proximity Read ↗

Linking molecular mechanisms to their evolutionary consequences: a primer.Semantic proximity Read ↗

Regulatory network structure determines patterns of intermolecular epistasis.Semantic proximity Read ↗

The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR.Semantic proximity Read ↗

The Energetics of Molecular Adaptation in Transcriptional RegulationSemantic proximity Read ↗

Evolutionary potential of transcription factors for gene regulatory rewiring.Semantic proximity Read ↗

Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon.Semantic proximity Read ↗

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read ↗

Epistasis and evolution: recent advances and an outlook for prediction.Semantic proximity Read ↗

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read ↗

On the mechanistic nature of epistasis in a canonical cis-regulatory element.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.