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Article

Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon.

Molecular biology and evolution - 25 Jun 2021

Karkare Kedar, Lai Huei-Yi, Azevedo Ricardo B R, Cooper Tim F

Abstract excerpt

Populations of Escherichia coli selected in constant and fluctuating environments containing lactose often adapt by substituting mutations in the lacI repressor that cause constitutive expression of the lac operon. These mutations occur at a high rate and provide a significant benefit. Despite this, eight of 24 populations evolved for 8,000 generations in environments containing lactose contained no detectable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33744956
DOI: 10.1093/molbev/msab077
PMCID: PMC8233506

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