Article
NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
PloS one - 1 Jan 2013
Tzeng Sheng-Tai, Tsai Ming-Hong, Chen Chi-Long, Lee Jing-Xing, Jao Tzu-Ming, Yu Sung-Liang, Yen Sou-Jhy, Yang Ya-Chien
Abstract excerpt
BACKGROUND: Genomic deletion at tumor suppressor loci is a common genetic aberration in human cancers. The study aimed to explore candidate tumor suppressor genes at chromosome 4q25-q28.2 and to delineate novel prognostic biomarkers associated with colorectal cancer (CRC). METHODS: Deletion mapping of chromosome 4q25-q28.2 was conducted in 114 sporadic CRC by loss of heterozygosity study with 11 microsatellite...
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