Article
Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer.
Human mutation - 1 Apr 2004
Baldinu Paola, Cossu Antonio, Manca Antonella, Satta Maria P, Sini Maria C, Rozzo Carla, Dessole Salvatore, Cherchi PierLuigi, Gianfrancesco Fernando, Pintus Adriana, Carboni Annangela, Deiana Angelo, Tanda Francesco, Palmieri Giuseppe
Abstract excerpt
Allelic deletions, which are suggestive for the presence of tumor suppressor genes, represent a common event in endometrial cancer (EC). Previous loss-of-heterozygosity studies for human chromosome 10q identified a candidate deletion interval at 10q25-q26, which we further narrowed to a 160-kb region at 10q26, bounded by markers D10S1236 and WIAF3299. Using a positional candidate approach, we identified three...
Topics
- Carcinoma
- Cell Line, Tumor
- Chromosomes, Human, Pair 10
- DNA Mutational Analysis
- Endometrial Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- Loss of Heterozygosity
- RNA, Messenger
- Sequence Analysis
- Tissue Distribution