Modulation of the CD4+ T-Cell Response by Helicobacter pylori Depends on Known Virulence Factors and Bacterial Cholesterol and Cholesterol α-Glucoside Content

Abstract excerpt

Helicobacter pylori blocks the proliferation of human CD4(+) T cells, facilitated by vacuolating exotoxin (VacA) and γ-glutamyl transpeptidase (GGT). H. pylori-triggered T-cell reactions in mice correlate with bacterial cholesterol and cholesterol α-glucoside content but their role in human cells is unclear. We characterized the effect of VacA, GGT, and cholesterol on T-helper 1, T-helper 2, T-regulatory and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eosinophilic Esophagitis
• Share to Helicobacter pylori-related gastroenterology studies
• Share to IL-33, ST2, and ILC Pathways