Article
Unexpected distribution of cKIT and BRAF mutations among southern Italian patients with sinonasal melanoma.
Dermatology (Basel, Switzerland) - 1 Jan 2013
Colombino Maria, Lissia Amelia, Franco Renato, Botti Gerardo, Ascierto Paolo A, Manca Antonella, Sini Maria Cristina, Pisano Marina, Paliogiannis Panagiotis, Tanda Francesco, Palmieri Giuseppe, Cossu Antonio
Abstract excerpt
BACKGROUND: Racial and geographic factors seem to affect the incidence of cutaneous and mucosal melanoma. OBJECTIVE: To investigate the occurrence of BRAF and cKIT impairments in patients with sinonasal melanoma in Southern Italy. METHODS: Eleven sinonasal melanomas were screened for BRAF mutations and cKIT alterations by immunohistochemistry (CD117), fluorescence in situ hybridization and sequencing analyses....
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