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Learning subgroup-specific regulatory interactions and regulator independence with PARADIGM

19 Jun 2013

Abstract excerpt

UNLABELLED: High-dimensional '-omics' profiling provides a detailed molecular view of individual cancers; however, understanding the mechanisms by which tumors evade cellular defenses requires deep knowledge of the underlying cellular pathways within each cancer sample. We extended the PARADIGM algorithm (Vaske et al., 2010, Bioinformatics, 26, i237-i245), a pathway analysis method for combining multiple '-omics'...

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PMID: 23813010
DOI: 10.1093/bioinformatics/btt229

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