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Article

Integrative pathway enrichment analysis of multivariate omics data.

Nature communications - 5 Feb 2020

Paczkowska Marta, Barenboim Jonathan, Sintupisut Nardnisa, Fox Natalie S, Zhu Helen, Abd-Rabbo Diala, Mee Miles W, Boutros Paul C, Reimand Jüri

Abstract excerpt

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part...

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Adenocarcinoma
Chromatin Immunoprecipitation
Databases, Factual
Gene Dosage
Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hippo Signaling Pathway

Metabolic Networks and Pathways

Sequence Analysis, RNA

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PMID: 32024846
DOI: 10.1038/s41467-019-13983-9
PMCID: PMC7002665

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