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Article

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation.

PloS one - 1 Jan 2013

Guha Minakshi, Castellanos-Rizaldos Elena, Makrigiorgos G Mike

Abstract excerpt

Non-small cell lung cancer (NSCLC) patients treated with small molecule EGFR inhibitors, such as gefitinib, frequently develop drug resistance due to the presence of secondary mutations like the T790M mutation on EGFR exon 20. These mutations may originate from small subclonal populations in the primary tumor that become dominant later on during treatment. In order to detect these low-level DNA variations in the...

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Identifiers

PMID: 23805327
DOI: 10.1371/journal.pone.0067782
PMCID: PMC3689726

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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