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Article

A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin.

The Journal of cell biology - 17 Jan 2005

Tsai Robert Y L, McKay Ronald D G

Abstract excerpt

Nucleostemin (NS) was identified as a stem cell- and cancer cell-enriched nucleolar protein that controls the proliferation of these cells. Here, we report the mechanism that regulates its dynamic shuttling between the nucleolus and nucleoplasm. The nucleolar residence of nucleostemin involves a transient and a long-term binding by the basic and GTP-binding domains, and a dissociation mechanism mediated by the...

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Identifiers

PMID: 15657390
DOI: 10.1083/jcb.200409053
PMCID: PMC2171593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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