Article
Inferring selection intensity and allele age from multilocus haplotype structure.
G3 (Bethesda, Md.) - 7 Aug 2013
Chen Hua, Slatkin Montgomery
Abstract excerpt
It is a challenging task to infer selection intensity and allele age from population genetic data. Here we present a method that can efficiently estimate selection intensity and allele age from the multilocus haplotype structure in the vicinity of a segregating mutant under positive selection. We use a structured-coalescent approach to model the effect of directional selection on the gene genealogies of neutral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
