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Article

The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.

Antiviral therapy - 1 Jan 2017

Shan Menglin, Shen Zhen, Sun Hua, Zheng Jianghua, Zhang Min

Abstract excerpt

BACKGROUND: Drug-resistant HBV mutants frequently arise during nucleoside/nucleotide analogue (NA) therapy, while the resistance mutations on polymerase also have consequent changes in the S protein. The enrichment of immune-escape mutations was negatively correlated with hepatitis B surface antigen (HBsAg) clearance under NA therapy. This study aims to characterize the variability of HBV polymerase and surface...

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Identifiers

PMID: 28300730
DOI: 10.3851/IMP3156

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