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Article

Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.

Antiviral research - 1 Dec 2012

Mirandola Silvia, Sebastiani Giada, Rossi Cristina, Velo Emanuela, Erne Elke Maria, Vario Alessandro, Tempesta Diego, Romualdi Chiara, Campagnolo Davide, Alberti Alfredo

Abstract excerpt

The evolution of hepatitis B virus (HBV) and the role of different variants during antiviral therapy may be influenced by HBV genotype. We have therefore analysed substitutions potentially related to nucleos(t)ide analogues (NAs) resistance at 42 positions within RT-region in a cohort of patients with chronic hepatitis B in relation to HBV-genotype. RT mutations analysis was performed by direct sequencing in 200...

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Identifiers

PMID: 23026293
DOI: 10.1016/j.antiviral.2012.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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