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Article

TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.

Human molecular genetics - 1 May 2012

An Peng, Wu Qian, Wang Hao, Guan Yu, Mu Mingdao, Liao Yijun, Zhou Daizhan, Song Pengkun, Wang Chunrong, Meng Liping, Man Qingqing, Li Lixiang, Zhang Jian, Wang Fudi

Abstract excerpt

A variety of conditions lead to anemia, which affects one-quarter of the world's population. Previous genome-wide association studies revealed a number of genetic polymorphisms significantly associated with plasma iron status. To evaluate the association of genetic variants in genes involved in i...

Read the complete abstract on PubMed

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Share to Anemia, Iron-Deficiency
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22323359
DOI: 10.1093/hmg/dds028

Genes

TMPRSS6
TFR2
BMP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22323359-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.PMID 22323359Read ↗

The role of TMPRSS6 gene polymorphism in iron resistance iron deficiency anaemia (IRIDA): a systematic review.Semantic proximity Read ↗

TMPRSS6 gene polymorphisms associated with iron deficiency anaemia among global populationSemantic proximity Read ↗

The role of TMPRSS6 gene variants in iron-related hematological parameters in Turkish patients with iron deficiency anemia.Semantic proximity Read ↗

TMPRSS6 Gene Polymorphism and Serum Hepcidin in Iron Deficiency AnemiaSemantic proximity Read ↗

Impact of TMPRSS6 Genetic Variants on Maternal Iron Status in Pregnancy: A Systematic Review.Semantic proximity Read ↗

Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia.Semantic proximity Read ↗

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.Semantic proximity Read ↗

Genetic analysis of TMPRSS6 gene in Saudi female patients with iron deficiency anemia.Semantic proximity Read ↗

Association of common TMPRSS6 and TF gene variants with hepcidin and iron status in healthy rural Gambians.Semantic proximity Read ↗

A single-nucleotide polymorphism in transferrin is associated with soluble transferrin receptor in Chinese adolescents.Semantic proximity Read ↗

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.Semantic proximity Read ↗

Novel Pathogenic Variants of TMPRSS6 Gene in a Girl with Iron Refractory Iron Deficiency Anemia (IRIDA)Semantic proximity Read ↗

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