Article
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.
Nature genetics - 1 Nov 2009
Benyamin Beben, Ferreira Manuel A R, Willemsen Gonneke, Gordon Scott, Middelberg Rita P S, McEvoy Brian P, Hottenga Jouke-Jan, Henders Anjali K, Campbell Megan J, Wallace Leanne, Frazer Ian H, Heath Andrew C, de Geus Eco J C, Nyholt Dale R, Visscher Peter M, Penninx Brenda W, Boomsma Dorret I, Martin Nicholas G, Montgomery Grant W, Whitfield John B
Abstract excerpt
We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10(-20)), transferrin saturation (combined P = 2.2 x 10(-23)) and erythrocyte mean cell volume (MCV, combined P = 1.1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the...
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