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Article

Loss of SOX9 Expression Is Associated with PSA Recurrence in ERG-Positive and PTEN Deleted Prostate Cancers

1 Jun 2015

Abstract excerpt

The transcription factor SOX9 plays a crucial role in normal prostate development and has been suggested to drive prostate carcinogenesis in concert with PTEN inactivation. To evaluate the clinical impact of SOX9 and its relationship with key genomic alterations in prostate cancer, SOX9 expression was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers. Data on ERG status...

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PMID: 26030748
DOI: 10.1371/journal.pone.0128525

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Loss of SOX9 Expression Is Associated with PSA Recurrence in ERG-Positive and PTEN Deleted Prostate CancersPMID 26030748Read ↗

ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancerSemantic proximity Read ↗

SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with <i>PTEN</i> Loss to Drive Tumor FormationSemantic proximity Read ↗

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SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrenceSemantic proximity Read ↗

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Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with <i>SLC45A3‐ERG</i> gene rearrangement and an unfavorable clinical courseSemantic proximity Read ↗

Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parametersSemantic proximity Read ↗

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