Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

doi:10.1371/journal.ppat.1012904

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Article

Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

PLoS pathogens - 1 Feb 2025

Zhang Fuquan, Joiner Susan, Linehan Jacqueline M, Pintilii Florin, Nazari Tamsin, Argentina Fabio, Preston Connor, Taema Maged, Cunningham Thomas J, Asante Emmanuel A, Mok Tzehow, Mead Simon, Brandner Sebastian, Collinge John, Wadsworth Jonathan D F

Abstract excerpt

The epizootic prion disease of cattle, bovine spongiform encephalopathy (BSE), caused variant Creutzfeldt-Jakob disease (vCJD) in humans following dietary exposure. Codon 129 polymorphism of the human prion protein gene (PRNP), encoding either methionine (M) or valine (V), dictates the propagation of distinct human prion strains and up to now all but one neuropathologically confirmed vCJD patients have had a...

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Topics

Animals
Cattle
Female
Humans
Male
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Brain

Codon

Creutzfeldt-Jakob Syndrome

Encephalopathy, Bovine Spongiform

Genotype

Heterozygote

Mice, Transgenic

Prion Proteins

Prions

Source

Open in PubMed Open full text

Identifiers

PMID: 39977481
DOI: 10.1371/journal.ppat.1012904
PMCID: PMC11841882

Genes

PRNP

Provenance

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