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Article

The Contribution of Notch Signaling to Glioblastoma via Activation of Cancer Stem Cell Self-renewal

18 Jan 2012

Abstract excerpt

The microenvironment in which stem cells are found, commonly referred to as the stem cell niche, is formed by various supporting cells, extracellular matrix elements, and other factors that maintain stem cells in a self-renewing, stem-like state (see Fuchs et al1 for a review). Like their normal counterparts, so-called cancer stem cells (CSCs), the small subpopulation of tumor cells capable of initiating new...

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PMID: 22251985
DOI: 10.1227/01.neu.0000410937.38828.6f

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