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Article

Effect of rosiglitazone on liver structure and function in genetically diabetic Akita mice.

Basic & clinical pharmacology & toxicology - 1 Nov 2013

Hemmeryckx Bianca, Gaekens Marijke, Gallacher David J, Lu Hua Rong, Lijnen Henri Roger

Abstract excerpt

Genetically diabetic Akita mice, kept on a high-fat and high-cholesterol diet, and treated with the peroxisome proliferator-activated receptor-γ agonist rosiglitazone (10 mg/kg per day during 4 months), displayed rosiglitazone-induced side effects, similar to those observed in patients, including weight and fat gain and early signs of hypertrophic cardiomyopathy. As several cases of hepatotoxicity were reported...

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Source

Identifiers

PMID: 23789962
DOI: 10.1111/bcpt.12104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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