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Article

Non-invasive neural stem cells become invasive in vitro by combinatorial FGF2 and BMP4 signaling

1 Jan 2013

Abstract excerpt

Neural stem cells (NSCs) typically show efficient self-renewal and selective differentiation. Their invasion potential, however, is not well studied. In this study, Sox2-positive NSCs from the E14.5 rat cortex were found to be non-invasive and showed only limited migration in vitro. By contrast, FGF2-expanded NSCs showed a strong migratory and invasive phenotype in response to the combination of FGF2 and BMP4....

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PMID: 23788430
DOI: 10.1242/jcs.125757

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