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A human embryonic stem cell–based model reveals the cell of origin of FOXR2-activated CNS neuroblastoma

1 Jan 2024

Abstract excerpt

Background: FOXR2-activated central nervous system (CNS) neuroblastoma (CNS NB-FOXR2) is a recently identified subtype of brain tumor characterized by the elevated expression of the transcription factor FOXR2 mainly due to genomic rearrangements. However, the precise pathogenic mechanisms, including the cell type of origin, remain elusive. Methods: A gene expression analysis of patient tumors was performed to...

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PMID: 39220247
DOI: 10.1093/noajnl/vdae144

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