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Article

Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Jun 2013

Schmid Thomas, Günther Stefan, Mendler Luca, Braun Thomas

Abstract excerpt

Regulation of sexual reproduction and energy homeostasis are closely interconnected, but only few efforts were made to explore the impact of gonadotropic neurons on metabolic processes. We have used Nscl-2 mutant mice suffering from adult onset of obesity and hypogonadotropic hypogonadism to study effects of gonadotropin releasing hormone (GnRH) neurons on neuronal circuits controlling energy balance....

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Source

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Identifiers

PMID: 23785158
DOI: 10.1523/JNEUROSCI.5287-12.2013
PMCID: PMC6618601

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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