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Article

Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice.

PloS one - 1 Jan 2009

Ruschke Karen, Ebelt Henning, Klöting Nora, Boettger Thomas, Raum Kay, Blüher Matthias, Braun Thomas

Abstract excerpt

BACKGROUND: In mammals the interplay between the peripheral nervous system (PNS) and adipose tissue is widely unexplored. We have employed mice, which develop an adult onset of obesity due to the lack the neuronal specific transcription factor Nscl-2 to investigate the interplay between the nervous system and white adipose tissue (WAT). METHODOLOGY: Changes in the architecture and innervation of WAT were compared...

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Identifiers

PMID: 19436734
DOI: 10.1371/journal.pone.0005516
PMCID: PMC2677458

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