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Article

Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007

Cogliati Tiziana, Delgado-Romero Petra, Norwitz Errol R, Guduric-Fuchs Jasenka, Kaiser Ursula B, Wray Susan, Kirsch Ilan R

Abstract excerpt

Pubertal development is impaired in mice lacking the basic helix-loop-helix transcription factor Nhlh2. The mechanisms underlying changes in reproduction in Nhlh2-deficient mice (Nhlh2(-/-)) are unclear. Here we show that hypothalamic GnRH-1 content is reduced in adult Nhlh2(-/-) mice as is the number of GnRH-1 neurons localized to mid- and caudal hypothalamic regions. This reduction was detected postnatally...

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Identifiers

PMID: 17717072
DOI: 10.1210/me.2005-0337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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