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Article

Deletion of Otx2 in GnRH Neurons Results in a Mouse Model of Hypogonadotropic Hypogonadism

25 Mar 2011

Abstract excerpt

GnRH is the central regulator of reproductive function responding to central nervous system cues to control gonadotropin synthesis and secretion. GnRH neurons originate in the olfactory placode and migrate to the forebrain, in which they are found in a scattered distribution. Congenital idiopathic hypogonadotropic hypogonadism (CIHH) has been associated with mutations or deletions in a number of genes that...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 21436260
DOI: 10.1210/me.2010-0271

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Deletion of Otx2 in GnRH Neurons Results in a Mouse Model of Hypogonadotropic HypogonadismPMID 21436260Read ↗

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