Article
An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype.
Molecular cancer therapeutics - 1 Sept 2013
Larocca Cecilia, Cohen Joseph R, Fernando Romaine I, Huang Bruce, Hamilton Duane H, Palena Claudia
Abstract excerpt
The epithelial-mesenchymal transition (EMT) is a process associated with the metastasis of solid tumors as well as with the acquisition of resistance to standard anticancer modalities. A major initiator of EMT in carcinoma cells is TGF-β, which has been shown to induce the expression of several transcription factors ultimately responsible for initiating and maintaining the EMT program. We have previously...
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