Article
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells.
The Journal of clinical investigation - 1 Feb 2010
Fernando Romaine I, Litzinger Mary, Trono Paola, Hamilton Duane H, Schlom Jeffrey, Palena Claudia
Abstract excerpt
Metastatic disease is responsible for the majority of human cancer deaths. Understanding the molecular mechanisms of metastasis is a major step in designing effective cancer therapeutics. Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal tran...
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