Article
A Transcriptional Program for Detecting TGFβ-Induced EMT in Cancer.
Molecular cancer research : MCR - 1 May 2017
Foroutan Momeneh, Cursons Joseph, Hediyeh-Zadeh Soroor, Thompson Erik W, Davis Melissa J
Abstract excerpt
Most cancer deaths are due to metastasis, and epithelial-to-mesenchymal transition (EMT) plays a central role in driving cancer cell metastasis. EMT is induced by different stimuli, leading to different signaling patterns and therapeutic responses. TGFβ is one of the best-studied drivers of EMT, and many drugs are available to target this signaling pathway. A comprehensive bioinformatics approach was employed to...
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