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Article

TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms.

Annals of hematology - 1 Apr 2012

Martínez-Avilés Luz, Besses Carlos, Álvarez-Larrán Alberto, Torres Erica, Serrano Sergi, Bellosillo Beatriz

Abstract excerpt

Mutations in the TET2 and ASXL1 genes have been described in approximately 14% and 8% of patients, respectively, with classic myeloproliferative neoplasms (MPN), but their role as possible new diagnostic molecular markers is still inconclusive. In addition, other genes such as IDH1, IDH2, and c-CBL have also been reported in several myeloid neoplasms. We have studied the mutational status of TET2 (complete coding...

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Source

Identifiers

PMID: 21904853
DOI: 10.1007/s00277-011-1330-0

Genes

ASXL1
TET2
CBL
IDH1
IDH2
JAK2
MPL

Variants

Provenance

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Related research

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TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms.PMID 21904853Read ↗

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Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms.Semantic proximity Read ↗

Mutation analysis of <i>ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12,</i> and <i>TET2</i> in myeloproliferative neoplasmsSemantic proximity Read ↗

TET2 mutations in Ph-negative myeloproliferative neoplasms: identification of three novel mutations and relationship with clinical and laboratory findings.Semantic proximity Read ↗

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TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis.Semantic proximity Read ↗

Genetics of the myeloproliferative neoplasms.Semantic proximity Read ↗

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