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Article

Clinical Impact of Next-Generation Sequencing-Detected Mutations on Thrombotic Events in Myeloproliferative Neoplasms.

International journal of laboratory hematology - 1 Aug 2026

Yigitbasi Ahmet, Umit Elif Gulsum, Puyan Fulya Oz, Kirkizlar Hakki Onur, Kirkizlar Tugcan Alp, Can Nuray, Aygun Guray, Demir Ahmet Muzaffer

Abstract excerpt

INTRODUCTION: Myeloproliferative neoplasms (MPNs), encompassing polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are hematologic malignancies characterized by recurrent somatic mutations. Despite advances in next-generation sequencing (NGS), the genetic basis of thrombotic risk and bone marrow (BM) fibrosis in MPNs remains unclear. METHODS: Patients diagnosed with classical...

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Identifiers

PMID: 42045100
DOI: 10.1111/ijlh.70123
PMCID: PMC13357844

Genes

ASXL1
JAK2
TET2
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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