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Molecular genetics, therapeutics and RET inhibitor resistance for medullary thyroid carcinoma and future perspectives

28 Sept 2024

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare type of thyroid malignancy that accounts for approximately 1-2% of all thyroid cancers (TCs). MTC include hereditary and sporadic cases, the former derived from a germline mutation of rearrangement during transfection (RET) proto-oncogene, whereas somatic RET mutations are frequently present in the latter. Surgery is the standard treatment for early stage MTC, and the...

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PMID: 39342195
DOI: 10.1186/s12964-024-01837-x

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