Article
Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial.
JAMA neurology - 1 Aug 2013
Hanson Angela J, Bayer-Carter Jennifer L, Green Pattie S, Montine Thomas J, Wilkinson Charles W, Baker Laura D, Watson G Stennis, Bonner Laura M, Callaghan Maureen, Leverenz James B, Tsai Elaine, Postupna Nadia, Zhang Jing, Lampe Johanna, Craft Suzanne
Abstract excerpt
IMPORTANCE: Sporadic Alzheimer disease (AD) is caused in part by decreased clearance of the β-amyloid (Aβ) peptide breakdown products. Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid. OBJECTIVE: To characterize the lipidation states of Aβ...
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