Article
FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response.
Pharmacogenetics and genomics - 1 Sept 2013
Makowsky Robert, Wiener Howard W, Ptacek Travis S, Silva Miriam, Shendre Aditi, Edberg Jeffrey C, Portman Michael A, Shrestha Sadeep
Abstract excerpt
OBJECTIVE: Kawasaki disease (KD), response to intravenous immunoglobulin (IVIG) therapy, and associated coronary artery disease progression have been associated with genetic polymorphisms in Fc gamma receptor (FcγR) genes. However, it is not known whether the existing gene copy number (GCN) variability relates to KD treatment response, susceptibility, or associated sequelae. METHODS: The copy number of...
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