Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.

doi:10.1038/ng.981

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Article

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.

Nature genetics - 13 Nov 2011

Khor Chiea Chuen, Davila Sonia, Breunis Willemijn B, Lee Yi-Ching, Shimizu Chisato, Wright Victoria J, Yeung Rae S M, Tan Dennis E K, Sim Kar Seng, Wang Jie Jin, Wong Tien Yin, Pang Junxiong, Mitchell Paul, Cimaz Rolando, Dahdah Nagib, Cheung Yiu-Fai, Huang Guo-Ying, Yang Wanling, Park In-Sook, Lee Jong-Keuk, Wu Jer-Yuarn, Levin Michael, Burns Jane C, Burgner David, Kuijpers Taco W, Hibberd Martin L

Abstract excerpt

Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first...

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PMID: 22081228
DOI: 10.1038/ng.981

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ITPKC
MIA

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