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Article

FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms.

Frontiers in immunology - 1 Jan 2024

Uittenbogaard Paula, Netea Stejara A, Tanck Michael W T, Geissler Judy, Buda Piotr, Kowalczyk-Domagała Monika, Okarska-Napierała Magdalena, van Stijn Diana, Tacke Carline E, Burgner David P, Shimizu Chisato, Burns Jane C, Kuipers Irene M, Kuijpers Taco W, Nagelkerke Sietse Q

Abstract excerpt

Introduction: Kawasaki disease (KD) is a pediatric vasculitis that can result in coronary artery aneurysm (CAA) formation, which is a dangerous complication. Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma receptors (FcγRs), which reduces the binding of pathological immune complexes. However, ~20% of children have...

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Identifiers

PMID: 39359734
DOI: 10.3389/fimmu.2024.1323171
PMCID: PMC11445592

Genes

FCGR2A
FCGR3B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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