Article
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent.
Pharmacogenetics and genomics - 1 Aug 2013
Zuo Lingjun, Wang Ke-Sheng, Zhang Xiang-Yang, Li Chiang-Shan R, Zhang Fengyu, Wang Xiaoping, Chen Wenan, Gao Guimin, Zhang Heping, Krystal John H, Luo Xingguang
Abstract excerpt
OBJECTIVES: We have previously reported a top-ranked risk gene [i.e., serine incorporator 2 gene (SERINC2)] for alcohol dependence in individuals of European descent by analyzing the common variants in a genome-wide association study. In the present study, we comprehensively examined the rare variants [minor allele frequency (MAF)<0.05] in the NKAIN1-SERINC2 region to confirm our previous finding. MATERIALS AND...
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