Article
A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies.
Cellular and molecular life sciences : CMLS - 1 Nov 2016
Chan Jo-Anne, Howell Katherine B, Langer Christine, Maier Alexander G, Hasang Wina, Rogerson Stephen J, Petter Michaela, Chesson Joanne, Stanisic Danielle I, Duffy Michael F, Cooke Brian M, Siba Peter M, Mueller Ivo, Bull Peter C, Marsh Kevin, Fowkes Freya J I, Beeson James G
Abstract excerpt
Antibodies to blood-stage antigens of Plasmodium falciparum play a pivotal role in human immunity to malaria. During parasite development, multiple proteins are trafficked from the intracellular parasite to the surface of P. falciparum-infected erythrocytes (IEs). However, the relative importance of different proteins as targets of acquired antibodies, and key pathways involved in trafficking major antigens...
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