Article
Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins.
Molecular & cellular proteomics : MCP - 1 Feb 2013
Pasini Erica M, Braks Joanna A, Fonager Jannik, Klop Onny, Aime Elena, Spaccapelo Roberta, Otto Thomas D, Berriman Matt, Hiss Jan A, Thomas Alan W, Mann Matthias, Janse Chris J, Kocken Clemens H M, Franke-Fayard Blandine
Abstract excerpt
Malaria parasites actively remodel the infected red blood cell (irbc) by exporting proteins into the host cell cytoplasm. The human parasite Plasmodium falciparum exports particularly large numbers of proteins, including proteins that establish a vesicular network allowing the trafficking of proteins onto the surface of irbcs that are responsible for tissue sequestration. Like P. falciparum, the rodent parasite...
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