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Article

COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study.

Neuroscience letters - 25 Nov 2005

Poyurovsky Michael, Michaelovsky Elena, Frisch Amos, Knoll Gabriela, Amir Ilan, Finkel Boris, Buniak Feodor, Hermesh Haggai, Weizman Ronit

Abstract excerpt

This is the first study of a possible molecular genetic basis for schizophrenia with obsessive-compulsive disorder (OCD). We performed a case-control association study of the catechol-O-methyltransferase (COMT) Val158Met polymorphism in schizophrenia-OCD patients, OCD and healthy controls. One hu...

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Source

Identifiers

PMID: 16043283
DOI: 10.1016/j.neulet.2005.06.064

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16043283-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study.PMID 16043283Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Semantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder.Semantic proximity Read ↗

Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder.Semantic proximity Read ↗

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.Semantic proximity Read ↗

Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: preliminary results.Semantic proximity Read ↗

COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study.Semantic proximity Read ↗

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.Semantic proximity Read ↗

Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.Semantic proximity Read ↗

No association between anxiety disorders and catechol-O-methyltransferase polymorphism.Semantic proximity Read ↗

No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population.Semantic proximity Read ↗

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