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Article

The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010

Katerberg Hilga, Cath Danielle C, Denys Damiaan A J P, Heutink Peter, Polman Annemiek, van Nieuwerburgh Filip C W, Deforce Dieter L D, Bochdanovits Zoltán, van Balkom Anton J L M, den Boer Johan A

Abstract excerpt

Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the...

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Source

Identifiers

PMID: 19521967
DOI: 10.1002/ajmg.b.30971

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder.PMID 19521967Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

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