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Article

Pathophysiology of cubilin: of rats, dogs and men.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2002

Verroust Pierre J

Abstract excerpt

At variance from small solutes which are reabsorbed by transporters and channels, proteins present in the proximal convoluted tubule lumen are internalized by endocytosis via a vesicular system, transferred to the lysosomes and degraded. We summarize here recent data on cubilin, a 460 kDa peripheral protein which, together with megalin, serves as a multiligand receptor providing for the reabsorption of most...

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PMID: 12386289
DOI: 10.1093/ndt/17.suppl_9.55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Pathophysiology of cubilin: of rats, dogs and men.PMID 12386289Read ↗

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).Semantic proximity Read ↗

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In-depth phenotyping of a Donnai-Barrow patient helps clarify proximal tubule dysfunction.Semantic proximity Read ↗

AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2.Semantic proximity Read ↗

A Drosophila model for Dent's disease type 1 revealed impaired endoplasmic reticulum export of Cubilin as pathogenic mechanism.Semantic proximity Read ↗

Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease.Semantic proximity Read ↗

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Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration.Semantic proximity Read ↗

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.Semantic proximity Read ↗

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A <i>Drosophila</i> model for Dent’s disease reveals impaired ER export of Cubilin as pathogenic mechanismSemantic proximity Read ↗

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